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Post Doctoral Fellow

Job ID: req998
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is dedicated to improving human health through discovery and innovation in the biomedical sciences, focusing on cancer, AIDS, and emerging infectious diseases. 

Position Overview:

PROGRAM DESCRIPTION 

The Clinical PD Biomarkers Program is responsible for identification of biomarkers of response to new targeted agents entering clinical trials in the Developmental Therapeutics Program of the National Cancer Institute. The scope of work includes assay design, development, validation, fitness for purpose testing, transfer of assays to clinical laboratories, and clinical specimen analysis when required. The program facilitates mechanistic and performance analysis of putative anti-cancer agents, diagnostic tests, and therapeutic interventions to clinical applications, including distinct molecular signatures for cancer, refined molecular assays, and state-of-the-art imaging techniques that are too high-risk for industry or academia to pursue. 

KEY ROLES/RESPONSIBILITIES

  • Assisting in the development, validation, and application of quantitative multiplex assays of non-apoptotic cell death mechanisms on the Luminex platform to be used in assessing patient response to new anti-cancer agents
  • Designing ex vivo and in vivo experiments to test immunoassay reagents and efficacy of assays
  • Designing antigens for generation of antibodies
  • Writing statements of work for sub-contracted work
  • Monitoring development of monoclonal antibodies
  • Producing and characterizing recombinant proteins and/or peptides as calibrators
  • Developing and validating multiplex immunoassays of pharmacodynamic biomarkers on Luminex platform
  • Ensuring adequate specificity and analytical characteristics of reagents
  • Providing timely progress reports to Principal Scientist and preparing/performing presentations for management review
  • Writing abstracts/manuscripts for presentations in meetings and publication

BASIC QUALIFICATIONS

  • Possession of a Doctoral degree from an accredited college or university (according to CHEA) in biomedical research, biochemistry, chemistry, or engineering. Foreign degrees will be evaluated for U.S. equivalency.
  • Proficient in Microsoft office software, electronic data keeping and management, and basic knowledge of statistics applied in data reduction and analysis
  • No experience required beyond the Doctorate degree
  • Must be able to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS

  • Research performed in the area of understanding mechanisms of apoptotic and non-apoptotic cell death pathways
  • Experience in molecular biology techniques, protein/antibody characterization, and in vitro testing of inhibitors of apoptosis
  • Knowledge of statistics applied in data reduction and analysis

JOB HAZARDS OR REQUIREMENTS

  • Candidate will be working with or have the potential for exposure to infectious material(s) or Other Potentially Infectious Materials (OPIM), requiring medical clearance and immunization in accordance with protocol requirements.

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)