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Scientist I - Chemist, Drug Discovery

Job ID: req996
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA

The Frederick National Laboratory is dedicated to improving human health through discovery and innovation in the biomedical sciences, focusing on cancer, AIDS, and emerging infectious diseases. 

Position Overview:

Program Description:

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.


We offer an exciting opportunity for a Scientist I in Medicinal Chemistry in the area of fragment based drug discovery.  We are looking for a passionate researcher trained in medicinal or synthetic organic chemistry, with experience working on drug discovery projects. The Scientist I will help follow up on identified hits to advance drug discovery efforts.

  • Maintain a high level of productivity in a laboratory setting (90% of time in lab)
  • Generate and prepare synthetic targets based on fragment hits
  • Investigate, identify, develop, and optimize new methods/techniques (based on project requirements)
  • Work in a highly multidisciplinary team environment, collaborating with functional and technical experts to facilitate scientific achievement
  • Publish project-related research in high-impact journals or patent applications


  • Possession of a doctorate degree in a relevant discipline from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education)
  • Experience in medicinal chemistry
  • Strong background in organic synthesis and/or medicinal chemistry
  • Expertise in the design, synthesis, and characterization of pharmaceutically relevant small molecules
  • Familiarity with modern analytical technologies including: LCMS, NMR (1H, 13C, 2D techniques), HPLC, Flash chromatography
  • Must be able to obtain and maintain a clearance.


  • Experience of fragment based drug discovery
  • Knowledge of cancer drug discovery
  • Familiarity with common screening platforms used in cancer drug discovery
  • Ability to balance workload over multiple projects
  • Must be highly collaborative, self-motivated, and team-oriented

 Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)