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Bioinformatics Analyst IV

Job ID: req944
Facility: NIH
Location: NIH Campus 9000 Rockville Pike, Bethesda, MD 20892 USA

The Frederick National Laboratory is dedicated to improving human health through discovery and innovation in the biomedical sciences, focusing on cancer, AIDS, and emerging infectious diseases. 

Position Overview:

Within Leidos Biomedical Research Inc., the Clinical Monitoring Research Program Directorate (CMRPD) provides high-quality comprehensive and strategic operational support to the high-profile domestic and international clinical research initiatives of the National Cancer Institute (NCI), National Institute of Allergy and Infectious Diseases (NIAID), Clinical Center (CC), National Heart, Lung and Blood Institute (NHLBI), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Center for Advancing Translational Sciences (NCATS), National Institute of Neurological Disorders and Stroke (NINDS), and the National Institute of Mental Health (NIMH). Since its inception in 2001, CMRPD’s ability to provide rapid responses, high-quality solutions, and to recruit and retain experts with a variety of backgrounds to meet the growing research portfolios of NCI, NIAID, CC, NHLBI, NIAMS, NCATS, NINDS, and NIMH has led to the considerable expansion of the program and its repertoire of support services. CMRPD’s support services are strategically aligned with the program’s mission to provide comprehensive, dedicated support to assist National Institutes of Health (NIH) researchers in providing the highest quality of clinical research in compliance with applicable regulations and guidelines, maintaining data integrity, and protecting human subjects. For the scientific advancement of clinical research, CMRPD services include comprehensive clinical trials monitoring, regulatory, pharmacovigilance, protocol navigation and development, and programmatic and project management support for facilitating the conduct of 400+ Phase I, II, and III domestic and international trials on a yearly basis. These trials investigate the prevention, diagnosis, treatment of, and therapies for cancer, influenza, HIV, and other infectious diseases and viruses such as hepatitis C, tuberculosis, malaria, and Ebola virus; heart, lung, and blood diseases and conditions; parasitic infections; rheumatic and inflammatory diseases; and rare and neglected diseases. CMRPD’s collaborative approach to clinical research and the expertise and dedication of staff to the continuation and success of the program’s mission has contributed to improving the overall standards of public health on a global scale.

The Clinical Monitoring Research Program Directorate (CMRPD) provides bioinformatic support to the National Cancer Institute’s (NCI’s), Center for Cancer Research (CCR), Surgery Branch (SB). 


  • Works closely with the staff to develop and support the application of software tools needed for the analysis of complex datasets derived from high-throughput whole genome, whole exome, and RNA-seq analysis of tumor and T cell populations
  • Provides detailed analysis of complex datasets and provide summaries to SB Senior Investigators, post-doctoral fellows, and clinical fellows as needed
  • Works with the Principal Investigators to set goals, devise specific plans, and periodically review progress in projects to assist in the research and development of novel targeted immunotherapies
  • Focuses on generating and optimizing software tools used for the analysis of complex datasets derived from analysis of patient tumor and peripheral blood samples
  • Develops and optimizes a sequencing pipeline used to identify mutated T cell epitopes along with a variety of other software tools for analyzing high throughput sequencing data
  • Maintains expert knowledge of scientific principals and concepts, new and emerging computational methods and technologies and medical imaging principals
  • Initiates and prepares new research plans, proposals or methodologies
  • Develops new methods and validates the reliability of the methodology
  • Develops data triage and quality control evaluations for complex level assignments
  • Responsible for development and implementation of Standard Operating Procedures
  • Develops formal reporting of data utilized in presentations and/or publications
  • Conduct presentations of data at seminars and meetings
  • May supervisor lower level technical staff
  • This position is located in Bethesda, Maryland


  • Possession of a Bachelor’s degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in biomedical science/bioinformatics/math/computer related field (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency.
  • In addition to the education requirements, a minimum of eight (8) years of progressively responsible relevant experience
  • Strong background in Bioinformatics
  • Demonstrates proficiency coding in either R or Python
  • Experience with relevant scientific software applications such as Varscan and Annovar that are used for the analysis of high throughput sequencing results in order to optimize a pipeline used to identify somatic mutations that encode epitopes recognized by tumor-reactive T cells.
  • Proficiency with software packages such as Partek, which contains a variety of statistical tools for analyzing complex cell populations, including hierarchical clustering tools that will facilitate the classification of cells based upon gene expression patterns, gene ontology enrichment tools to group genes on the basis of their molecular function, and a chromosomal viewer that facilitates the visualization of chromosomal mapping data and copy number variation
  • Experience with working in a cGMP-like environment, which is needed to carry out studies that are relevant to patient treatments
  • Must be able to obtain and maintain a security clearance


  • Master's degree preferred
  • Basic knowledge and a degree in Computer Science
  • Experience with molecular biology techniques, clinical research and project management
  • Experience with next-generation sequence analysis
  • Proficiency in a variety of bioinformatics analysis tools
  • Excellent presentation skills that include written, oral communication
  • Experience with a variety of analysis tools that include Tophat, Samtools, Varscan and Annovar
  • Experience performing expression analysis
  • Experience working with single cell data
  • Familiarity with methods for T cell receptor sequence analysis

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)