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Research Associate II

Job ID: req923
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA

The Frederick National Laboratory is dedicated to improving human health through discovery and innovation in the biomedical sciences, focusing on cancer, AIDS, and emerging infectious diseases. 

Position Overview:

PROGRAM DESCRIPTION

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

KEY ROLES/RESPONSIBILITIES

The Sequencing Facility is a high throughput laboratory providing cutting edge next generation technologies to the National Cancer Institute. The candidate will be responsible for:

  • Assisting with next generation (NGS) sequencing for the core facility
  • Current platforms include the Illumina NovaSeq, NextSeq, MiSeq, iSeq, PacBio, and additional platforms in the future
  • All projects are of a highly specialized nature and require technical proficiency, problem solving skills and good judgment
  • Responsible for all ongoing daily activities including library prep and sequencer set up, maintenance of equipment, use of protocols, sample quality control and troubleshooting of problems with direct coordination of the supervisor
  • Requires adherence to strict safety protocols and may require the use of personal protective equipment

BASIC QUALIFICATIONS

  • Possession of a Bachelor’s degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for US equivalency
  • In addition to the education requirements, a minimum of five (5) years of related experience in molecular biology
  • Experience with production of NGS libraries, sample and library quality control, and sequencing machine set up is essential
  • Must be able to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS

  • Proficiency utilizing onboard sequencer and commercial bioinformatics tools, core or service facility experience and the ability to assist in new protocol development
  • Experience with multiple next generation sequencing technologies including Illumina NextSeq or NovaSeq 
  • Working knowledge of DNA hybridization, ligation, fragmentation, end polishing, PCR, automation using robotics, Agilent Bioanalyzer, nanodrop, qPCR, sterile/clean room techniques, and sample and process tracking through LIMS 
  • The ideal candidate must have the ability to organize and utilize reagents and samples for high-throughput analysis in support of genomic studies and two years proven experience in DNA sequencing, data review and stringent record keeping

JOB HAZARDS

  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)