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Research Associate II-Microscopy

Job ID: req898
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is dedicated to improving human health through discovery and innovation in the biomedical sciences, focusing on cancer, AIDS, and emerging infectious diseases. 

Position Overview:


The Clinical Pharmacodynamics Biomarkers Program is responsible for identification of biomarkers of response to new targeted agents entering clinical trials in the Developmental Therapeutics Program of the National Cancer Institute. The scope of work includes assay design, development, validation, fitness for purpose testing, transfer of assays to clinical laboratories, and clinical specimen analysis when required. PADIS facilitates mechanistic and performance analysis of putative anti-cancer agents, diagnostic tests, and therapeutic interventions to clinical applications, including distinct molecular signatures for cancer, refined molecular assays, and state-of-the-art imaging techniques that are too high-risk for industry or academia to pursue.


  • Operate confocal microscope to image multiplex immunofluorescence assays on fixed xenograft tissue sections and clinical specimen biopsies by following detailed technical SOPs for imaging
  • Perform data analysis using advanced quantitative image analysis software following detailed technical SOPs for image analysis
  • Assist in the development and validation of novel immunofluorescence assays with guidance from scientific staff
  • Support development and implementation of immunofluorescence assays in support of clinical studies and initiatives
  • Perform in vitro experiments using cell lines to test pharmacodynamic marker responses to novel anti-cancer therapeutics


  • Possession of a Bachelor’s degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in a related field (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency
  • In addition to educational requirements, a minimum of five (5) years related biomedical experience
  • Ability to communicate with project lead researchers in a demanding scientific environment is essential
  • Ability to maintain precise records.  Must be able to provide scientific reports including details of experimental procedures, results and conclusions to supervisor
  • Ability to be flexible to meet changing needs
  • Experience with advanced microscopy/imaging instrumentation, software and technologies
  • Experience in basic cell biology techniques is essential (in vitro drug treatments, antibody-based assays, immunofluorescence assays, cell lysate extraction, protein concentrations, western-blotting etc.)
  • Ability to develop, modify methods and techniques independently 
  • Ability to manage multiple projects simultaneously, and to adapt to frequent changes in project priorities, as well as be able to master novel technologies and instrumentation
  • Proficiency with Microsoft Office (Excel, Word and Powerpoint)
  • Must be able to obtain and maintain a security clearance


  • Experience with image analysis software or whole slide imaging
  • Experience with GraphPad software
  • Experience working in a GLP (or higher) environment.  Quantitative laboratory work preferred in biochemistry, molecular biology, cancer biology


  • Candidate will be working with or have the potential for exposure to infectious material(s) or Other Potentially Infectious Materials (OPIM), requiring medical clearance and immunization in accordance with protocol requirements
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)