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Post Doctoral Fellow, Microbiology/Cellular Immunology

Job ID: req1983
Employee Type: exempt full-time
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

 Position Overview:

PROGRAM DESCRIPTION

The Laboratory of Human Retrovirology and Immunoinformatics (LHRI) has collaborated with the National Institute of Allergy and Infectious Diseases (NIAID) and supported NIAID clinical trials for patients infected with HIV mutants resisting anti-retroviral therapy. LHRI has isolated the multiple-class drug-resistant (MDR) variants from patients and characterized each variant's drug sensitivity and infectivity. The study aims to define salvage therapy and develop novel therapy (chemotherapy and immunotherapy). During the investigation, LHRI has characterized the emergence of novel mutations on drug susceptibility and viral replication. LHRI is a pioneer in researching the anti-viral cytokine, Interleukin-27, DNA-repair protein (Ku70)-mediated innate immune response against HIV and other virus co-infection, and novel subsets of immune cells. LHRI maintains the Database for Annotation, Visualization and Integrated Discovery (DAVID)(https://david.ncifcrf.gov/).

KEY ROLES/RESPONSIBILITIES

The Postdoctoral Fellows will be involved in:

  • Investigation of the molecular mechanism of a novel subset of human primary macrophages resisting MDR virus infections
  • Characterization of the function of novel non-coding viral RNAs
  • In the study, the candidate may manipulate confocal microscope, fluorescence microscopy, FlowSight imaging flow cytometry, Sanger DNA seq, Nexseq, single-cell RNA-seq, Quanterix HD-X system, AKTA, and handing Big Data analysis
  • Publishing paper(s) and presenting the findings in the international or domestic scientific conference(s)

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) or eight (8) years of related experience.  Foreign degrees must be evaluated for U.S. equivalency 
  • No Experience required with the degree
  • Publication of first author paper(s)
  • Ability to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:

  • General molecular biology techniques (RNA and DNA extraction, RT-PCR, point-mutagenesis)
  • Tissue culture (primary human T cells, macrophages and dendritic cells)
  • DNA/RNA transfection and transduction
  • Knock down of genes by siRNA or shRNA
  • Western blotting and ELISA
  • Immunol precipitation (pull-down) assay
  • Handling of lentiviruses or other viruses (RNA or DNA viruses)
  • Knowledge of molecular virology or HIV virology
  • Statistical analysis skills

JOB HAZARDS

  • This position is subject to working with potential for exposing to infectious materials, requiring medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

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