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Scientist II

Job ID: req1949
Employee Type: exempt full-time
Facility: ATRF: Other
Location: 8560 Progress Drive, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

 Position Overview:


The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI’s intramural Center for Cancer Research (CCR). The dedicated units provide expertise in electron microscopy, protein characterization, mass spectrometry, protein expression, optical microscopy, and genomics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR), where CRTP scientists work collaboratively with intramural NCI investigators to provide research technologies and expertise.


The Molecular Pharmacology Program within CRTP conducts basic and translational research against lung cancer, including in vitro and in vivo models.    We focus on the following area: (1) The mechanism of anaphase catastrophe induced by CDK2 inhibition (2) combination therapy targeting anaphase catastrophe (3) USP18-ISG15 protein degradation pathway as a target for lung cancer therapy (4) combination therapy of retinoids and immune checkpoint inhibitors.  Our work uses a broad range of technology including biochemical assays, imaging and microscope, cancer mouse models, genetic and cell biology assays, etc.

  • Independently conduct research project, including generating hypothesis, designing projects, conducting experiments, analyzing data, writing manuscript and publishing
  • Independently conduct experiments using biochemistry, molecular biology and pharmacologic approaches and methods
  • Present research project in scientific community
  • Ensure effective operation of laboratory equipment and serve as the point of contact for instrument repairs
  • Direct, coordinate, and maintain an adequate inventory of research lab glassware, materials, and laboratory equipment
  • Perform other related duties as assigned by a responsible authority
  • Organize and participate in vendor negotiations, product and software evaluations, tutorials, and facility modifications 


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) in a field related to pharmacology, molecular pharmacology, experimental therapeutics, cancer therapy or drug development or eight (8) years of related experience.  Foreign degrees must be evaluated for U.S. equivalency
  • In addition to the education requirement, a minimum of two (2) years of progressively responsible experience
  • Experience working in cancer research, pharmacology, or other human disease research
  • Ability to conduct experiments using biochemistry, molecular biology, and other methods (hand-on experience)
  • Ability to obtain and maintain a security clearance


Candidates with these desired skills will be given preferential consideration:

  • Experience laboratory management
  • Experience in pharmacology or cancer biology research
  • Multiple first-authored publication in peer-reviewed scientific journals
  • Multiple co-authored publication in peer-reviewed scientific journals


  • This position is subject to working with or have potential for exposure to animal(s) and/or animal material(s)
  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)