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Post Doctoral Fellow, Viral Immunology & Pathogenesis

Job ID: req1929
Employee Type: exempt full-time
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

 Position Overview:

PROGRAM DESCRIPTION

The Laboratory of Human Retrovirology and Immunoinformatics (LHRI), Applied/Developmental Directorate, conducts Basic research, Translational Research, and Bioinformatics research.  The goals of  LHRI studies are to support NIAID/NIH clinical research for HIV-infected individuals. LHRI has characterized the roles of novel mutations in the clinical isolated HIV strains, investigates the function of integrated proviral DNA, and develops a novel therapy for patients who infect with multiple-class drug-resistant (MDR) HIV variants. LHRI has identified Interleukin-27 and Ku70 as a novel anti-HIV cytokine and a novel host factor to induce novel innate immune responses. LHRI continues investigating the molecular mechanism of regulation of virus budding, assembly, and maturation to define a potential target for developing a novel therapy for the MDR virus.

KEY ROLES/RESPONSIBILITIES

The Postdoctoral Fellow will be involved in:

  • Characterization of HIV GagPol assembly, budding and maturation using several molecular biology, immunology, and microbiology techniques (qPCR, WB, Immune precipitation, confocal microscope, AMNIS (imaging flow cytometry), FPLC, cloning and constructing expression plasmids, knockdown or knock-in of gene of interests using (either siRNA or CRISPR). NGS
  • Publishing paper(s) and presenting the findings in the international or domestic scientific conference(s)

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) or eight (8) years of related experience.  Foreign degrees must be evaluated for U.S. equivalency
  • No Experience required with a Doctorate degree
  • Publication of authored paper(s)
  • Ability to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:

  • General molecular biology techniques (RNA extraction, RT-PCR, genomic DNA isolation, construction of expression plasmids), tissue culture (primary human cells: T cells and macrophages, and cell lines), transfection, western blotting, Immunol precipitation (pull down) assay, Sanger or NGS DNA sequence
  • Handling of lentiviruses or other virus (RNA or DNA viruses)
  • Tissue culture (cell line or primary cells)
  • Knowledge of molecular virology or HIV virology
  • Statistical analysis skills

JOB HAZARDS

  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

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