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Scientist II, Single Cell Analysis Facility

Job ID: req1834
Employee Type: exempt full-time
Facility: NIH
Location: NIH Campus 9000 Rockville Pike, Bethesda, MD 20892 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public’s interest.  

 Position Overview:


The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI’s intramural Center for Cancer Research (CCR). The dedicated units provide expertise in electron microscopy, protein characterization, mass spectrometry, protein expression, optical microscopy, and genomics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR), where CRTP scientists work collaboratively with intramural NCI investigators to provide research technologies and expertise.


We are seeking a highly motivated Scientist II to join the Single Cell Analysis Facility (SCAF) of the NCI Center for Cancer Research (CCR). The SCAF provides dedicated single cell sequencing and related technology support to basic and translational cancer research.

  • Provide project support on advanced single cell methods in support of CCR Investigators
  • Contribute to experimental design consultations and advise on sample preparation methods for single cell sequencing
  • Design and carry out experiments to test and validate emerging single cell methods
  • Work with other SCAF staff members to provide training and education in single cell methods
  • Is expected to author publications in peer reviewed scientific journals


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for U.S. equivalency
  • In addition to the education requirement, a minimum of two (2) years of progressively responsible experience
  • Strong background in cell and molecular biology, with familiarity of current single cell sequencing methods
  • Experience in next generation sequencing, including quality control, library preparation and data handling
  • Familiarity with diverse sample types and processing methods, including cell suspensions and tissue blocks / sections
  • Ability to obtain and maintain a security clearance


Candidates with these desired skills will be given preferential consideration:

  • Knowledge and background experience in cancer biology and immunology
  • Familiarity with downstream single cell sequencing applications
  • Experience in standard histo-pathology methods and microscopy
  • Experience working in a core facility or other team-based environment
  • Detail-oriented, and able to manage multiple projects simultaneously
  • Demonstrated ability to learn new technologies quickly
  • Excellent written and verbal communications skills


  • This position is subject to working with or have potential for exposure to animal(s) and/or animal material(s)
  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)