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Research Associate II

Job ID: req1803
Employee Type: exempt full-time
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public’s interest.  

 Position Overview:

PROGRAM DESCRIPTION

The Laboratory of Human Retrovirology and Immunoinformatics (LHRI) is a translational research laboratory (Bench-to-Bed side research) under the Clinical Services Program in Applied and Development Research Directorate. Researchers in the LHRI conduct basic and applied science to support NIAID clinical trials for HIV- and SARS-CoV-2-infected patients. Utilizing molecular biology, cell biology, microbiology and bioinformatics tools, researchers have investigated immune and viral responses to viral infection using clinical samples (blood and tissues from infected patients and/or normal healthy donors) and studied the molecular mechanisms of immunological and/or virological failures in HIV-infected patients. Main goals of the LHRI are to define fundamentals in immune or viral response, to develop novel immunotherapies and to elucidate salvage therapies for treatment failures in the NIAID clinical trials.

 KEY ROLES/RESPONSIBILITIES

 The Research Associate II will be directly supervised by the lab’s Scientist and will:

  • Independently perform multiple tasks handling infectious material, to include blood and serum of both HIV- and SARS-CoV-2- infected patients, under BL2* lab settings
  • Be involved in developing/standardization of new assays and evaluate the reliability of the methodology
  • Responsible for data and quality control evaluation
  • Formally report data/results, including presentation in scientific conferences and/or publications. Assays related to this position include but are not limited to following: DNA, RNA and protein extraction, ELISA, immunofluorescence, real-time PCR, Western blotting, transfection, transformation, cloning of genes of interest, construction of expression vectors, reporter assays and establishment of cell lines. NGS

BASIC QUALIFICATIONS

  • Possession of Bachelor’s degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) or four (4) years relevant experience in lieu of degree.  Foreign degrees must be evaluated for U.S. equivalency
  • In addition to the education requirement, a minimum of five (5) years of progressively responsible experience
  • Ability to: Function independently in a research environment with minimum supervision, requiring originality and judgment; independently evaluate the suitability and quality control of research
  • Knowledge of: basic subject matter of molecular biology, biochemistry, immunology, microbiology, and cell biology; advanced data reporting techniques using PowerPoint and statistical analysis software, basic laboratory techniques including working under sterile conditions and strictly adhering to safety procedures

PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:

  • Master’s degree
  • Molecular biology skills: Protein/DNA/RNA extraction, Western blotting, real-time PCR

JOB HAZARDS

  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

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