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Electron Microscopist

Job ID: req1773
Employee Type: exempt full-time
Facility: ATRF: Other
Location: 8560 Progress Drive, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public’s interest.  

 Position Overview:


The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI’s intramural Center for Cancer Research (CCR). The dedicated units provide expertise in electron microscopy, protein characterization, mass spectrometry, protein expression, optical microscopy, and genomics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR), where CRTP scientists work collaboratively with intramural NCI investigators to provide research technologies and expertise.


  • General laboratory duties including but not limited to prepare reagents, order lab supplies, maintain EM sample logbook
  • Process and embed biological samples in an epoxy resin for the thin-sectioned Electron Microscopy (EM)
  • Use of sharps (e.g. razor blades and scalpels) for trimming the EM sample blocks
  • Make thin sections (50 to 100nm) with a diamond knife and ultra-microtome and mount the sections on grids
  • Post stain the grids and carbonize in a vacuum evaporator
  • Operate and maintain EM (transmission EM and scanning EM)
  • Examine the samples in the EM and capture the digital images


  • Possession of Bachelor’s degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in a field related to biomedical research or four (4) years relevant experience in lieu of degree.  Foreign degrees must be evaluated for U.S. equivalency
  • In addition to the education requirement, a minimum of five (5) years of progressively responsible related experience
  • Knowledge of or experience with electron microscopes
  • Knowledge of processing biological samples for the microscopes (TEM and SEM)
  • Basic knowledge of ultra-structure of biological samples
  • Ability to obtain and maintain a security clearance


Candidates with these desired skills will be given preferential consideration:

  • Familiarity with the operation and routine maintenance Thermo Fisher, formally FEI, T-12 and T-20;  Hitachi H7000 series and S4500 scanning electron microscopes
  • Familiarity with operation of ultra-microtomes (Leica UC series) using a diamond knife


  • This position is subject to working with or have potential for exposure to animal(s) and/or animal material(s)
  • This position is subject to working with or have potential for exposure to infectious material, requiring
  • This position is subject to working with radioactive material and requires to become an approved radiation worker medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)