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Research Associate I, Pre Clinical

Job ID: req1768
Employee Type: exempt full-time
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public’s interest.  

 Position Overview:


The Laboratory Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. The Center for Advanced Preclinical Research (CAPR) within LASP develops preclinical model systems for evaluation of cancer therapeutics and biomarker discovery, to facilitate the translation of research findings to the clinic. Mouse models for cancer are developed or retooled for application to studies assessing small molecule drugs, immunotherapy, and other novel treatments. 


The RAI will perform a key role in supporting multiple preclinical studies:

  • Conduct experimental procedures in laboratory mice with a focus on cancer models
  • Animal identification such as tail clipping and ear notching
  • Weekly body weights
  • Animal health observations
  • Monitor phenotypes and treatment responses
  • Dose by several compound administration routes/methodologies
  • Perform experiments including surgical procedures
  • Tumor detection and measurement by various methods
  • Collect blood and tissues
  • Perform necropsies in mice
  • Data entry and management in several databases and Excel workbooks
  • Maintenance of real time animal colony database
  • Learn, understand, and implement required compliance protocols (e.g. Animal Care and Use Committee registries), animal welfare guidelines, and standard operating procedures (SOPs)
  • Excellent technical proficiency, judgment and organizational skills are required to effectively manage a complex workload
  • Assignments are performed independently and following all applicable regulations, policies, procedures and standards governing animal welfare 
  • Work involves the use of potentially hazardous material or may be located in areas where such materials are used 
  • Work may require the use of personal protective equipment and requires adherence to strict safety protocols
  • Schedule may include weekend and holiday hours


  • Possession of Bachelor’s degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) or four (4) years relevant experience in lieu of degree.  Foreign degrees must be evaluated for U.S. equivalency
  • In addition to educational requirements, a minimum of two (2) years progressively responsible job-related biomedical experience
  • Experience in performing experimental procedures in rodents
  • Ability to maintain precise, accurate records
  • Knowledge of standard operating procedures for animal facilities and the basic requirements for maintaining laboratory animals and performing scientific procedures involving animal testing and data collection
  • Ability to obtain and maintain a security clearance


Candidates with these desired skills will be given preferential consideration:

  • Experience in dosing rodents by various routes (IP, IV, oral gavage)
  • Hands-on experience with rodent cancer models
  • Ability to multi-task
  • Computer/data entry skills
  • Excellent written and oral communications skills
  • Excellent observation and organization skills
  • Experience with wet lab methods such as genotyping or tissue culture are a plus but not required


  • This position is subject to working with or have potential for exposure to animal(s) and/or animal material(s)
  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations
  • This position is subject to atmospheric conditions that would require the usage of a respirator, requiring a medical clearance
  • This position is subject to working in or have the potential to exposure to high noise levels for extended periods of time requiring medical clearance
  • This position is subject to the environmental conditions such as working outdoors, high humidity areas indoors, dampness and chilling, dry atmospheric conditions, etc. as part of the job
  • This position is subject to working with radioactive material and requires to become an approved radiation worker

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)