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Preclinical Research Associate I or II, Functional Genomics

Job ID: req1453
Employee Type: exempt full-time
Facility: Rockville: 9615 MedCtrDr
Location: 9615 Medical Center Drive, Rockville, MD 20850 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public’s interest.  

 Position Overview:


The Cancer Genomics Research Laboratory (CGR) investigates the contribution of germline and somatic genetic variation to cancer susceptibility and outcomes in support of the NCI's Division of Cancer Epidemiology and Genetics (DCEG), the world’s most comprehensive cancer epidemiology research group.  CGR is located at the NCI-Shady Grove campus in Rockville, MD and operated by Leidos Biomedical Research, Inc.  We care deeply about discovering the genetic and environmental determinants of cancer, and new approaches to cancer prevention, through our contributions to the molecular, genetic, and epidemiologic research of the 70+ investigators in DCEG.  Working in concert with epidemiologists, biostatisticians and basic research scientists in DCEG’s intramural research program, CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer. This includes the design and analysis of high throughput studies using various types of “–omics” technologies such as array- and sequence-based genome-wide association studies, studies of tumor characteristics using integrated genomic data analysis, and molecular epidemiologic studies based on novel assays focused on the metabolome and microbiome.


  • Perform molecular biology and cell-based assays for the Functional Genomics team within CGR
  • Perform cell culture based experiments including transfection/transduction, siRNA/shRNA techniques and cellular functional analysis assays (i.e. xCELLigence, Seahorse)
  • Perform downstream applications on cultured cell lines using molecular biology techniques including PCR, RTPCR, DNA/RNA extraction, biochemical techniques including western blotting, and Immunological methods including FACS and/or single cell sequencing
  • Troubleshoot and develop assays independently with input from Senior Scientific staff


This position may be filled at the Research Associate I or Research Associate II level.

 To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a Bachelor’s degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education)
  • Foreign degrees must be evaluated for U.S. equivalency
  • Research Associate I - two (2) years of relevant experience in a field related to molecular biology, chemistry, biochemistry or other life science
  • Research Associate II - five (5) years of relevant experience in a field related to molecular biology, chemistry, biochemistry or other life science
  • Cell culture experience including familiarity with transfection/transduction, siRNA/shRNA
  • Molecular biology techniques including PCR, RTPCR, DNA/RNA extraction
  • Ability to work independently
  • Must be able to obtain and maintain a clearance.


Candidates with these desired skills will be given preferential consideration:

  • Cellular functional analysis (i.e. xCELLigence, Seahorse) experience
  • Experience with Immunological methods including FACS and/or single cell sequencing
  • Experience with biochemical techniques including western blotting
  • Next Generation Sequencing experience – Illumina or Ion torrent
  • Experience with CRISPR
  • ChIP-Seq Experience
  • Assay Development experience


  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations
  • This position is subject to the environmental conditions such as working outdoors, high humidity
    areas indoors, dampness and chilling, dry atmospheric conditions, etc. as part of the job

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)