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Scientist I, Electron Microscopist

Job ID: req1220
Employee Type: exempt full-time
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public’s interest.  

 Position Overview:


The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI’s intramural Center for Cancer Research (CCR). The dedicated units provide expertise in electron microscopy, protein characterization, mass spectrometry, protein expression, optical microscopy and genomics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR), where CRTP scientists work collaboratively with intramural NCI investigators to provide research technologies and expertise

At the Center for Molecular Microscopy (CMM), the cryo-EM section is focused on determining structures of proteins and macromolecular complexes to high resolution. We use both single particle analysis with cryo-electron microscopy, as well as cryo-electron tomography coupled with sub-tomogram averaging, to determine structures of protein complexes. The Center for Molecular Microscopy have been in operation since late 2013, offering efficient operation and top-quality service by technically savvy, professional and dedicated staff. We are serving the entire NIH community, mainly CCR/NCI investigators, with a state-of-the-art instrumentation, which includes a Titan Krios coupled with a Falcon 3 and a K2 cameras as well as a Talos Arctica with Phase Plate, and a K3 camera, that allow us to perform structural studies of soluble and membrane protein complexes at near atomic resolution.


  • Provide technical advice to investigators on sample preparation, and data collection.
  • Operate TEM microscopes, specifically Titan Krios, Talos Arctica and Talos L120C; task will include loading samples, screening, and performing high-resolution data collection for single particle studies as well as cryo-electron tomography.
  • Manage maintenance for the Titan Krios as well as associated instruments (T12, Talos L120C, Arctica).
  • Interact closely with colleagues within the CMM as well as with collaborators.


  • Possession of a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation in Biological Sciences, Structural Biology, or related discipline (foreign degrees must be evaluated for U.S. equivalency)
  • Experience with Cryo-EM, Cryo-electron tomography, and high-resolution single-particle analysis
  • Must be detail-oriented and able to manage multiple projects simultaneously
  • Strong laboratory skills
  • Must be able to obtain and maintain a security clearance


  • Experience with negative stain and other specimen preparation techniques for EM as micro-ED

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)