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Scientist I

Job ID: req1063
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is dedicated to improving human health through discovery and innovation in the biomedical sciences, focusing on cancer, AIDS, and emerging infectious diseases. 

Position Overview:

PROGRAM DESCRIPTION
The Molecular Pharmacology Laboratory supports the Molecular Pharmacology Branch (MPB) of the Developmental Therapeutics Program (DTP), Division of Cancer Treatment & Diagnosis (DCTD). Efforts concentrate in two main areas: (1) to identify and implement conditions that increase the translational capacity of cancer organoid-based screens to enable identification of active therapies for patient derived models and in DCTD-sponsored clinical trials and (2) direct testing of mechanistic hypotheses on which DCTD-sponsored clinical trials and preclinical development can be built.
 

KEY ROLES/RESPONSIBILITIES

  •  The Scientist I will play a key role in the generation of organoid cultures from patient biopsies, in their characterization (i.e., high content imaging) and in evaluating the feasibility for a patient-derived organoid co-clinical screening protocol
  •  The Scientist I will play a key role in evaluating mechanistic hypotheses for drug responses in the context of targeted clinical trials using cancer cell lines, Patient Derived Xenograft (PDX) lines, organoids, or other 3D models, by applying molecular biology techniques to achieve gene modulation and elucidating pathways of interest
  •  The successful candidate will be responsible for executing experimental procedures according to project plans approved by the Laboratory Head

 BASIC QUALIFICATIONS

Possession of a Doctoral degree from an accredited college or university according to the Council for Higher Education Accreditation in a field related to pharmacology, molecular pharmacology, experimental therapeutics, cancer therapy or drug development.  Foreign degrees must be evaluated for U.S. equivalency

  •  Eight (8) years related experience in a field related to pharmacology, molecular pharmacology, experimental therapeutics, cancer therapy or drug development in lieu of degree
  •  Practical experience with 3D cultures
  •  Practical experience with basic molecular and cellular biology techniques including PCR cloning, mutagenesis, transient and stable expression methodologies and si/shRNA mediated gene knockdown
  •  Ability to effectively interpret experimental data and some experience with molecular pharmacology and its methodologies to determine compounds mechanisms of action
  •  Thorough understanding of genetics, genomics, and gene regulation
  •  Must be able to obtain and maintain a security clearance 

PREFERRED QUALIFICATIONS

  •  Expertise with 3D cultures immunofluorescence and/or high content imaging, high-throughput drug screens
  • Expertise applying molecular biological techniques, including gene editing methodologies, to address cancer drug mechanism of action questions
  •  Expertise using gene expression/mutation profiles to identify genes, proteins, and pathways that determine drug sensitivity

JOB HAZARDS

  • This position is subject to working with or have potential for exposure to animal(s) and/or
    animal material(s)
  • This position is subject to working with or have potential for exposure to infectious material,
    requiring medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)