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Post Doctoral Fellow, Novel Drug Discovery

Job ID: req1026
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is dedicated to improving human health through discovery and innovation in the biomedical sciences, focusing on cancer, AIDS, and emerging infectious diseases. 

Position Overview:

PROGRAM DESCRIPTION         

The Laboratory of Human Retrovirology and Immunoinformatics (LHRI), Clinical Services Program, Applied/ Developmental Directorate, has investigated the mechanism of multiple drug resistance (MDR) in HIV-infected patients using techniques of molecular biology, virology, cellular biology and bioinformatics under a collaboration with the National Institute of Allergy and Infectious Diseases (NIAID)/NIH. Our goal is to develop novel immune therapy for MDR-infected patients who have failed from current available chemotherapies.  LHRI has isolated several mutants of novel MDR HIV and characterized drug-resistant profiles and discovered  Interleukin-27 and Interferon-lambda1 as novel anti-MDR cytokines, SPTBN1(in macorphages) and YB-1 (in T cells) as host essential factors for virus infection, which are potential novel drug targets,  a total of 72 novel micro RNAs (miRNAs) possessing anti-viral/tumor properties and 44 novel long none-coding RNAs (LncRNAs) of unknown function (LncRUF).

KEY ROLES/RESPONSIBILITIES

This Post Doctoral Fellow will:

  • Investigate molecular mechanism(s) of ant-viral effect by the novel miRNAs and function of the LncRUF
  • Identify and characterize host factor proteins associated with viral infection in a certain cell type
  • Be involved in an on-going study to improve a gene-editing technology using CRISPR/Cas9 
  • Present finding(s) in scientific conference(s) and publish multiple papers

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a PhD or MD/PhD degree from an accredited college or university according to the Council for Higher Education Accreditation.  Foreign degrees must be evaluated for U.S. equivalency
  •  0~2 years of experience in human immunology, virology or molecular biology
  •  Molecular biology techniques (e.g. RT-PCR, qPCR, cloning of gene, point mutagenesis, DNA sequence, transfection of DNA, protein purification, ELISA,WB, Immuno precipitation, purification of genomic DNA, RNA and plasmid DNA)
  •  Knowledge of cell signaling or gene regulation
  •  Analysis of DNA sequence using Sequencher software
  •  Statistical analysis, handling of Prizm software
  •  Publication of at least one (1) first author paper in a peer review journal
  •  Must be able to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:  

  • Knowledge of function of none-coding RNAs and innate immune responses
  • Experience of tissue culture (primary human cells), RNA transfection, RNAseq
  • Experience of gene-editing or silencing of targets utilizing CRISPR/Cas9, shRNA or siRNA
  • Experience of  FRET/alpha screening or confocal microscopic analysis
  • Handling of infectious virus (e.g.HIV, HSV, SeV, KHSV, CMV) with appropriate knowledge of virus lifecycle

JOB HAZARDS

  • This position is subject to working with or have potential for exposure to infectious material,
    requiring medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)